PTRF Products
(Polymerase I and Transcript Release Factor (PTRF))
Categories
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009].
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Featured PTRF Categories
PTRF Antibodies
High quality antibodies with extensive validation data.
PTRF ELISA Kits
Reliable ELISA kits for a wide range of species.
PTRF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTRF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN2779886
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN391621
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN6264525
Quantity
100 μL
Datasheet
Datasheet
Recommended PTRF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969451
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975616
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5592511
Quantity
96 tests
Datasheet
Datasheet
Recommended PTRF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316890
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316889
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3086655
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PTRF products
: "Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 317, Issue 1, pp. L99-L108, (2019) (PubMed).: "Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin." in: Experimental cell research, Vol. 352, Issue 1, pp. 113-122, (2017) (PubMed).
: "Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 6, pp. 585-602, (2015) (PubMed).
: "Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid." in: PLoS ONE, Vol. 9, Issue 1, pp. e85045, (2014) (PubMed).
: "Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle." in: Biochimica et biophysica acta, Vol. 1843, Issue 2, pp. 346-51, (2013) (PubMed).
: "Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 10, pp. 2109-24, (2010) (PubMed).
: "SDPR induces membrane curvature and functions in the formation of caveolae." in: Nature cell biology, Vol. 11, Issue 7, pp. 807-14, (2009) (PubMed).
: "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes." in: The Journal of cell biology, Vol. 185, Issue 7, pp. 1259-73, (2009) (PubMed).
: "PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function." in: Cell, Vol. 132, Issue 1, pp. 113-24, (2008) (PubMed).
Synonyms and alternative names related to PTRF
caveolae associated protein 1 L homeolog (cavin1.L), polymerase I and transcript release factor (PTRF), caveolae associated protein 1 (cavin1), caveolae associated protein 1 (CAVIN1), caveolae associated protein 1b (cavin1b), caveolae associated 1 (Cavin1), caveolae associated protein 1 (Cavin1), 2310075E07Rik, AW546441, Cav-p60, CAVIN, Cavin, cavin-1, CAVIN1, CGL4, fd20g07, MGC53017, MGC89141, PTRF, ptrf, wu:fd20g07, zgc:162917Protein level used designations for PTRF
- polymerase I and transcript release factor
- leucine zipper protein
- leucine-zipper protein
- polymerase I and transcript release factor-like
- RNA polymerase I and transcript release factor
- TTF-I interacting peptide 12
- cavin-1
- cav-p60
- cavin
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