PTPRN Products
(Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))
Categories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
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Featured PTPRN Categories
PTPRN Antibodies
High quality antibodies with extensive validation data.
PTPRN ELISA Kits
Reliable ELISA kits for a wide range of species.
PTPRN Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTPRN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (3)
Cat. No.
ABIN7439915
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN948357
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (2)
Cat. No.
ABIN7444055
Quantity
100 μL
Datasheet
Datasheet
Recommended PTPRN ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962149
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969757
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969756
Quantity
96 tests
Datasheet
Datasheet
Recommended PTPRN Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124688
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124687
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316877
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTPRN products
: "Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2." in: Journal of translational medicine, Vol. 14, Issue 1, pp. 278, (2016) (PubMed).: "Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates." in: Journal of proteomics, Vol. 75, Issue 9, pp. 2611-20, (2012) (PubMed).
: "Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2." in: The Journal of biological chemistry, Vol. 283, Issue 8, pp. 4674-81, (2008) (PubMed).
: "ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 2, pp. 674-9, (2008) (PubMed).
: "RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose." in: The Journal of endocrinology, Vol. 195, Issue 2, pp. 313-21, (2007) (PubMed).
: "High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes." in: Diabetes Care, Vol. 30, Issue 4, pp. 932-8, (2007) (PubMed).
: "ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies." in: Journal of autoimmunity, Vol. 18, Issue 2, pp. 191-6, (2002) (PubMed).
Synonyms and alternative names related to PTPRN
protein tyrosine phosphatase, receptor type N (PTPRN), protein tyrosine phosphatase, receptor type, N (Ptprn), protein tyrosine phosphatase, receptor type N (Ptprn), protein tyrosine phosphatase, receptor type, Na (ptprna), protein tyrosine phosphatase, receptor type N L homeolog (ptprn.L), fc43c04, IA-2, Ia-2, ia-2, IA-2/PTP, IA2, ia2, ICA512, ica512, mIA-A, mKIAA4064, ptprn, R-PTP-N, r-ptp-n, wu:fc43c04Protein level used designations for PTPRN
- ICA 512
- PTP IA-2
- islet cell antigen 2
- islet cell antigen 512
- islet cell autoantigen 3
- protein tyrosine phosphatase-like N
- receptor-type tyrosine-protein phosphatase-like N
- ICA512
- R-PTP-N
- islet cell autoantigen 512
- protein tyrosine phosphatase, receptor-type, N
- 105 kDa islet cell antigen
- BEM-3
- ICA105
- PTPLP
- brain-enriched membrane-associated protein tyrosine phosphatase
- insulinoma antigen-2
- receptor type N protein tyrosine phosphatase
- protein tyrosine phosphatase, receptor type, N
- protein tyrosine phosphatase, receptor type, Na
- protein tyrosine phosphatase, receptor type N L homeolog
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