PTPN12 Products
(Protein Tyrosine Phosphatase G1 (PTPN12))
Categories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
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Featured PTPN12 Categories
PTPN12 Antibodies
High quality antibodies with extensive validation data.
PTPN12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTPN12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (14)
Cat. No.
ABIN7075292
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, ICC
Validations
- (4)
Cat. No.
ABIN2855422
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7239389
Quantity
200 μL
Datasheet
Datasheet
Recommended PTPN12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730261
Quantity
96 tests
Datasheet
Datasheet
Recommended PTPN12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124676
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316826
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316828
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTPN12 products
: "Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer." in: Oncotarget, Vol. 6, Issue 13, pp. 11704-13, (2015) (PubMed).: "PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling." in: Oncogene, Vol. 33, Issue 8, pp. 1047-54, (2014) (PubMed).
: "Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12." in: Molecular and cellular biology, Vol. 33, Issue 12, pp. 2458-69, (2013) (PubMed).
Synonyms and alternative names related to PTPN12
protein tyrosine phosphatase, non-receptor type 12 (PTPN12), protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), P19-PTP, PTP-P19, PTP-PEST, PTPG1, Ptpg1, RKPTPProtein level used designations for PTPN12
- protein-tyrosine phosphatase G1
- tyrosine-protein phosphatase non-receptor type 12
- MPTP-PEST
- protein-tyrosine phosphatase P19
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