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PTPN11 Proteins

(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
PTPN11 Protein (AA 1-460) (GST tag) PTPN11 Protein (AA 1-460) (GST tag) PTPN11 Protein (AA 1-460) (GST tag) (ABIN1316822)

PTPN11 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

PTPN11 Protein (His tag) PTPN11 Protein (His tag) PTPN11 Protein (His tag) (ABIN7197591)

PTPN11 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active

PTPN11 Protein (AA 2-521) (His tag) (ABIN7505167)

PTPN11 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

PTPN11 Proteins by Grade

Find PTPN11 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PTPN11 Proteins by Origin

Find PTPN11 Proteins for a variety of species such as anti-Human PTPN11, anti-Rat PTPN11, anti-Mouse PTPN11. The species listed below are among those available. Click on a link to go to the corresponding products.

PTPN11 Proteins by Source

Here you will find PTPN11 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PTPN11 Proteins by Protein Type

Here you can find PTPN11 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PTPN11 Proteins by Application

Find PTPN11 Proteins validated for a specific application such as SDS, WB, ELISA, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PTPN11 Proteins by Biological Activity

Find PTPN11 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular PTPN11 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316822
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7197591
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505167
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397573
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3149973
Quantity 2 mg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN5855056
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2730110
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6382351
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1474246
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PTPN11 Proteins

Jo, Park, Lee, Ahn, Kim, Park, Choi: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).

Aliases for PTPN11 Proteins

protein tyrosine phosphatase, non-receptor type 11 (PTPN11) Proteins
protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) Proteins
protein tyrosine phosphatase, non-receptor type 11 S homeolog (ptpn11.S) Proteins
protein tyrosine phosphatase, non-receptor type 11, a (ptpn11a) Proteins
protein tyrosine phosphatase, non-receptor type 11, b (ptpn11b) Proteins
2700084A17Rik Proteins
AW536184 Proteins
BPTP3 Proteins
bptp3 Proteins
CFC Proteins
cfc Proteins
fa14b09 Proteins
NS1 Proteins
ns1 Proteins
PTP-1D Proteins
ptp-2 Proteins
PTP1D Proteins
PTP2C Proteins
ptp2c Proteins
ptpn11 Proteins
ptpn11-a Proteins
ptpn11-b Proteins
SAP-2 Proteins
SH-PTP2 Proteins
SH-PTP3 Proteins
SHP-2 Proteins
shp-2 Proteins
SHP2 Proteins
Shp2 Proteins
shp2 Proteins
Syp Proteins
SYP Proteins
wu:fa14b09 Proteins
wu:fi24f03 Proteins
zgc:55388 Proteins
zgc:63553 Proteins
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