PTPN11 Products
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Categories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
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Featured PTPN11 Categories
PTPN11 Antibodies
High quality antibodies with extensive validation data.
PTPN11 ELISA Kits
Reliable ELISA kits for a wide range of species.
PTPN11 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTPN11 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN1098117
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (7)
Cat. No.
ABIN3016707
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, FACS
Validations
- (6)
Cat. No.
ABIN184604
Quantity
100 μg
Datasheet
Datasheet
Recommended PTPN11 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958958
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Semi-Quantitative Cell ELISA
Validations
Cat. No.
ABIN2747888
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380082
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended PTPN11 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1316822
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7197591
Quantity
200 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505167
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PTPN11 products
: "Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis." in: Molecular immunology, Vol. 91, pp. 134-144, (2017) (PubMed).: "Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells." in: Journal of Cancer, Vol. 6, Issue 2, pp. 151-9, (2015) (PubMed).
: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).
: "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma." in: Gut, Vol. 63, Issue 9, pp. 1457-67, (2014) (PubMed).
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).
: "A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells." in: Blood, Vol. 118, Issue 6, pp. 1504-15, (2011) (PubMed).
: "Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis." in: Cancer cell, Vol. 19, Issue 5, pp. 629-39, (2011) (PubMed).
: "Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2837-49, (2011) (PubMed).
: "Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8003-12, (2010) (PubMed).
: "Mitochondrial DNA haplogroup 'R' is associated with Noonan syndrome of south India." in: Mitochondrion, Vol. 10, Issue 2, pp. 166-73, (2010) (PubMed).
Synonyms and alternative names related to PTPN11
protein tyrosine phosphatase, non-receptor type 11 (PTPN11), protein tyrosine phosphatase, non-receptor type 11 (Ptpn11), protein tyrosine phosphatase, non-receptor type 11 S homeolog (ptpn11.S), protein tyrosine phosphatase, non-receptor type 11, a (ptpn11a), protein tyrosine phosphatase, non-receptor type 11, b (ptpn11b), 2700084A17Rik, AW536184, BPTP3, bptp3, CFC, cfc, fa14b09, NS1, ns1, PTP-1D, ptp-2, PTP1D, PTP2C, ptp2c, ptpn11, ptpn11-a, ptpn11-b, SAP-2, SH-PTP2, SH-PTP3, SHP-2, shp-2, SHP2, Shp2, shp2, Syp, SYP, wu:fa14b09, wu:fi24f03, zgc:55388, zgc:63553Protein level used designations for PTPN11
- PTP-2C
- protein-tyrosine phosphatase 1D
- protein-tyrosine phosphatase 2C
- tyrosine-protein phosphatase non-receptor type 11
- SH2 domain-containing protein tyrosine phosphatase-2
- protein-tyrosine phosphatase SYP
- PTP-1D
- SH-PTP2 protein tyrosine phosphatase non-receptor type 11
- SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
- SHP-2
- encodes catalytic domain
- protein tyrosine phosphatase SH-PTP2
- protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
- SH-PTP2
- cSH-PTP2
- non-receptor type protein tyrosine phosphatase SHP2
- phosphotyrosyl-protein phosphatase
- protein tyrosine phosphatase, non-receptor type 11 S homeolog
- LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11
- protein-tyrosine phosphatase SHP-2a
- protein tyrosine phosphatase, non-receptor type 11, b
- protein-tyrosine phosphatase SHP-2b
- shp3 protein
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