PTPN1 Products
(Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
Categories
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008].
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Featured PTPN1 Categories
PTPN1 Antibodies
High quality antibodies with extensive validation data.
PTPN1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PTPN1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTPN1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (7)
Cat. No.
ABIN5542667
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey
Application
WB, IHC, FACS, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN1500496
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Validations
- (4)
Cat. No.
ABIN725975
Quantity
100 μL
Datasheet
Datasheet
Recommended PTPN1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969752
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969751
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958957
Quantity
96 tests
Datasheet
Datasheet
Recommended PTPN1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124680
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN934895
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666832
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PTPN1 products
: "Brain-Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease." in: Journal of the American Heart Association, Vol. 10, Issue 6, pp. e018322, (2021) (PubMed).: "Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models." in: Oncology reports, Vol. 34, Issue 4, pp. 2047-53, (2016) (PubMed).
: "Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet." in: Journal of hepatology, Vol. 63, Issue 3, pp. 713-21, (2016) (PubMed).
: "Memory and PTPIP51--a new protein in hippocampus and cerebellum." in: Molecular and cellular neurosciences, Vol. 64, pp. 61-73, (2015) (PubMed).
: "LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 1, pp. 140-8, (2014) (PubMed).
: "Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression." in: Biomolecules, Vol. 2, Issue 1, pp. 122-42, (2014) (PubMed).
: "The known interactome of PTPIP51 in HaCaT cells - inhibition of kinases and receptors." in: The international journal of biochemistry & cell biology, (2014) (PubMed).
: "IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 11, pp. 1969-79, (2013) (PubMed).
: "The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 31, pp. 12647-55, (2013) (PubMed).
: "PTPIP51 in protein interactions: regulation and in situ interacting partners." in: Cell biochemistry and biophysics, Vol. 63, Issue 3, pp. 211-22, (2012) (PubMed).
Synonyms and alternative names related to PTPN1
protein tyrosine phosphatase, non-receptor type 1 (PTPN1), protein tyrosine phosphatase, non-receptor type 1 (Ptpn1), protein tyrosine phosphatase, non-receptor type 1 (ptpn1), protein tyrosine phosphatase, non-receptor type 1 L homeolog (ptpn1.L), CPTP1, Ptp, PTP-1B, PTP-HA2, PTP1B, ptp1b, PTPN1, wu:fk54h03Protein level used designations for PTPN1
- protein tyrosine phosphatase, non-receptor type 1
- tyrosine-protein phosphatase non-receptor type 1
- tyrosine-protein phosphatase non-receptor type 1-like
- protein tyrosine phosphatase, placental
- protein-tyrosine phosphatase 1B
- protein-protein-tyrosine phosphatase HA2
- protein-tyrosine phosphatase HA2
- PTP-1B
- fk54h03
- protein tyrosine phosphatase 1b
- non-receptor protein tyrosine phosphatase
- phosphoprotein phosphatase
- tyrosine phosphatase 1B
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