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PTK6 Products

(PTK6 Protein tyrosine Kinase 6 (PTK6))

Categories

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

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Featured PTK6 Categories

PTK6 Antibodies

High quality antibodies with extensive validation data.

PTK6 ELISA Kits

Reliable ELISA kits for a wide range of species.

PTK6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PTK6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
  • (3)
Cat. No. ABIN519483
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (2)
Cat. No. ABIN392105
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7263521
Quantity 200 μL
Datasheet Datasheet

Recommended PTK6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958992
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN5519121
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380961
Quantity 96 tests
Datasheet Datasheet

Recommended PTK6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316783
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7317095
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7320007
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our PTK6 products

Xu, Ye, Wu, He, Tan, Xiao, Wu, Yu, Mai, Li, Peng, Huang, Li, Zhang, Zhu, Qin: "Overexpression of PTK6 predicts poor prognosis in bladder cancer patients." in: Journal of Cancer, Vol. 8, Issue 17, pp. 3464-3473, (2018) (PubMed).

Akl, Foudah, Ebrahim, Meyer, El Sayed: "The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling." in: Marine drugs, Vol. 12, Issue 4, pp. 2282-304, (2014) (PubMed).

Foudah, Sallam, Akl, El Sayed: "Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors." in: European journal of medicinal chemistry, Vol. 73, pp. 310-24, (2014) (PubMed).

Chen, Ma, Cao, Huang, Zeng, Wen: "Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma." in: Medical oncology (Northwood, London, England), Vol. 31, Issue 12, pp. 317, (2014) (PubMed).

Akl, Ayoub, Mohyeldin, Busnena, Foudah, Liu, Sayed: "Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models." in: PLoS ONE, Vol. 9, Issue 5, pp. e97622, (2014) (PubMed).

Sallam, Mohyeldin, Foudah, Akl, Nazzal, Meyer, Liu, El Sayed: "Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling." in: Organic & biomolecular chemistry, Vol. 12, Issue 28, pp. 5295-303, (2014) (PubMed).

Falkenberg, Anastasov, Höfig, Bashkueva, Lindner, Höfler, Rosemann, Aubele: "Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo." in: Molecular oncology, Vol. 9, Issue 1, pp. 282-94, (2014) (PubMed).

Liu, Zhang, Zhong, Li, Liu, Lin, Wu, Zeng: "Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma." in: Journal of translational medicine, Vol. 11, pp. 59, (2013) (PubMed).

Li, Rix, Fang, Bai, Edwards, Colinge, Bennett, Gao, Song, Eschrich, Superti-Furga, Koomen, Haura: "A chemical and phosphoproteomic characterization of dasatinib action in lung cancer." in: Nature chemical biology, Vol. 6, Issue 4, pp. 291-9, (2010) (PubMed).

Derry, Prins, Ray, Tyner: "Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells." in: Oncogene, Vol. 22, Issue 27, pp. 4212-20, (2003) (PubMed).

Synonyms and alternative names related to PTK6

protein tyrosine kinase 6 (PTK6), PTK6 protein tyrosine kinase 6 (Ptk6), protein tyrosine kinase 6 (Ptk6), PTK6 protein tyrosine kinase 6b (ptk6b), BRK, Sik, tks, Tksk, zgc:153964

Protein level used designations for PTK6

  • PTK6 protein tyrosine kinase 6
  • breast tumor kinase
  • protein-tyrosine kinase 6
  • protein-tyrosine kinase BRK
  • tyrosine-protein kinase BRK
  • protein tyrosine kinase 6
  • src-related intestinal kinase
  • tyrosine kinase identified from skin
  • protein-tyrosine kinase 6-like
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