PTK2B Products
(PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
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This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PTK2B Categories
PTK2B Antibodies
High quality antibodies with extensive validation data.
PTK2B ELISA Kits
Reliable ELISA kits for a wide range of species.
PTK2B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTK2B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (4)
Cat. No.
ABIN745763
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, PLA
Validations
- (5)
Cat. No.
ABIN515514
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (5)
Cat. No.
ABIN560841
Quantity
100 μg
Datasheet
Datasheet
Recommended PTK2B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN1981726
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN2748576
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380820
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended PTK2B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316780
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1778387
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509123
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTK2B products
: "Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment." in: Cell reports, Vol. 18, Issue 8, pp. 1946-1957, (2017) (PubMed).: "Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis." in: Bone, Vol. 74C, pp. 58-68, (2015) (PubMed).
: "Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2." in: Cancer letters, Vol. 329, Issue 2, pp. 164-73, (2013) (PubMed).
: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).
: "The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5636-44, (2008) (PubMed).
: "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons." in: Journal of cell science, Vol. 120, Issue Pt 17, pp. 3034-44, (2007) (PubMed).
: "Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells." in: Journal of virology, Vol. 80, Issue 3, pp. 1167-80, (2006) (PubMed).
: "The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).
: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, (2004) (PubMed).
"Fresh concepts in dental design." in: Journal of the California Dental Association, Vol. 32, Issue 5, pp. 365-6, (2004) (PubMed).
Synonyms and alternative names related to PTK2B
protein tyrosine kinase 2 beta (PTK2B), PTK2 protein tyrosine kinase 2 beta (Ptk2b), protein tyrosine kinase 2 beta (Ptk2b), protein tyrosine kinase 2aa (ptk2aa), CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, fak1b, FAK2, PKB, PTK, ptk2.2, ptk2b, PYK2, Pyk2, RAFTK, Raftk, si:ch1073-355e8.1Protein level used designations for PTK2B
- CAK-beta
- FADK 2
- PTK2B protein tyrosine kinase 2 beta
- calcium-dependent tyrosine kinase
- calcium-regulated non-receptor proline-rich tyrosine kinase
- cell adhesion kinase beta
- focal adhesion kinase 2
- proline-rich tyrosine kinase 2
- protein kinase B
- protein-tyrosine kinase 2-beta
- related adhesion focal tyrosine kinase
- cellular adhesion kinase beta
- protein tyrosine kinase 2 beta
- CADTK
- CAK beta
- PTK2 protein tyrosine kinase 2 beta
- fakb
- protein tyrosine kinase 2.2
- protein tyrosine kinase 2aa
- protein tyrosine kinase 2b
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