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PTGDS Products

(Prostaglandin D2 Synthase (PTGDS))

Categories

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008].

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Featured PTGDS Categories

PTGDS Antibodies

High quality antibodies with extensive validation data.

PTGDS ELISA Kits

Reliable ELISA kits for a wide range of species.

PTGDS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PTGDS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7432472
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7426007
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7164874
Quantity 100 μg
Datasheet Datasheet

Recommended PTGDS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (4)
Cat. No. ABIN6574195
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969645
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969244
Quantity 96 tests
Datasheet Datasheet

Recommended PTGDS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124606
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314800
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316723
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PTGDS products

Hamed, Laila-Al-Ayadhi, Osman, Elkhawad, Bjørklund, Qasem, Zayed, El-Ansary: "Determination of neuroinflammatory biomarkers in autistic and neurotypical Saudi children." in: Metabolic brain disease, Vol. 34, Issue 4, pp. 1049-1060, (2020) (PubMed).

Trimarco, Forese, Alfieri, Lucente, Brambilla, Dina, Pieragostino, Sacchetta, Urade, Boizet-Bonhoure, Martinelli Boneschi, Quattrini, Taveggia: "Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination." in: Nature neuroscience, Vol. 17, Issue 12, pp. 1682-92, (2014) (PubMed).

Huang, Huang, Lee, Yeh, Lin, Yu: "18F-glutathione conjugate as a PET tracer for imaging tumors that overexpress L-PGDS enzyme." in: PLoS ONE, Vol. 9, Issue 8, pp. e104118, (2014) (PubMed).

Matsumoto, Eguchi, Oda, Yamane, Tarutani, Ozawa, Hayashi, Nakae, Horie, Urade: "Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 75, Issue 4, pp. 897-904, (2011) (PubMed).

Takeda, Takahashi, Yoshizawa, Shibahara: "Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes." in: Journal of biochemistry, Vol. 148, Issue 2, pp. 139-48, (2010) (PubMed).

Huang, Lyu, Tseng, Chang, Hsu, Kuo, Chu, Wu, Ro, Huang, Chen: "Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy." in: Journal of neuroimmunology, Vol. 206, Issue 1-2, pp. 100-5, (2009) (PubMed).

Le Mée, Hennebert, Ferrec, Wülfert, Morfin: "7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes." in: Steroids, Vol. 73, Issue 11, pp. 1148-59, (2008) (PubMed).

Lovell, Lynn, Xiong, Quinn, Kaye, Markesbery: "An aberrant protein complex in CSF as a biomarker of Alzheimer disease." in: Neurology, Vol. 70, Issue 23, pp. 2212-8, (2008) (PubMed).

Kanekiyo, Ban, Aritake, Huang, Qu, Okazaki, Mohri, Murayama, Ozono, Taniike, Goto, Urade: "Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 15, pp. 6412-7, (2007) (PubMed).

Synonyms and alternative names related to PTGDS

phosphogluconate dehydrogenase (PGD), hematopoietic prostaglandin D synthase (HPGDS), prostaglandin D2 synthase (PTGDS), hematopoietic prostaglandin D synthase (Hpgds), prostaglandin D2 synthase (brain) (Ptgds), prostaglandin D2 synthase (Ptgds), prostaglandin D synthase (LOC100009453), prostaglandin D2 synthase 21kDa (brain) (PTGDS), 6PGD, 21kDa, GSTS, GSTS1-1, H-PGDS, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, PH2DISO, Ptgds2, Ptgs3

Protein level used designations for PTGDS

  • 6-phosphogluconate dehydrogenase, decarboxylating
  • GST class-sigma
  • glutathione S-transferase sigma
  • glutathione-dependent PGD synthase
  • glutathione-dependent PGD synthetase
  • glutathione-requiring prostaglandin D synthase
  • hematopoietic prostaglandin D2 synthase
  • prostaglandin-H2 D-isomerase
  • PGD2 synthase
  • beta-trace protein
  • cerebrin-28
  • glutathione-independent PGD synthase
  • glutathione-independent PGD synthetase
  • lipocalin-type prostaglandin D synthase
  • lipocalin-type prostaglandin-D synthase
  • prostaglandin D synthase
  • prostaglandin-D2 synthase
  • glutathione S-transferase
  • prostaglandin D2 synthase 2, hematopoietic
  • H-PGDS
  • prostaglandin-D synthase
  • prostaglandin D2 synthase (21 kDa, brain)
  • PGDS
  • PGDS2
  • Prostaglandin D synthase
  • prostaglandin D2 synthase 21kDa (brain)
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