PTBP1 Products
(Polypyrimidine Tract Binding Protein 1 (PTBP1))
Categories
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured PTBP1 Categories
PTBP1 Antibodies
High quality antibodies with extensive validation data.
PTBP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PTBP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTBP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (7)
Cat. No.
ABIN185079
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP, IHC (p)
Validations
- (7)
Cat. No.
ABIN562502
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN6146371
Quantity
100 μL
Datasheet
Datasheet
Recommended PTBP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5592507
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206857
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN2870197
Quantity
96 tests
Datasheet
Datasheet
Recommended PTBP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124528
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316690
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316692
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTBP1 products
: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).: "Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells." in: PLoS ONE, Vol. 7, Issue 7, pp. e41099, (2012) (PubMed).
: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).
: "Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein." in: Journal of viral hepatitis, Vol. 17, Issue 9, pp. 618-23, (2010) (PubMed).
: "Polypyrimidine tract-binding protein interacts with coxsackievirus B3 RNA and influences its translation." in: The Journal of general virology, Vol. 91, Issue Pt 5, pp. 1245-55, (2010) (PubMed).
: "Interactions between PTB RRMs induce slow motions and increase RNA binding affinity." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 260-77, (2010) (PubMed).
: "Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping." in: Molecular cell, Vol. 36, Issue 6, pp. 996-1006, (2010) (PubMed).
: "The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 1894-9, (2010) (PubMed).
: "Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing." in: Molecular cell, Vol. 9, Issue 3, pp. 649-58, (2002) (PubMed).
Synonyms and alternative names related to PTBP1
polypyrimidine tract binding protein 1 (PTBP1), polypyrimidine tract binding protein 1 S homeolog (ptbp1.S), polypyrimidine tract-binding protein (NAEGRDRAFT_80143), polypyrimidine tract-binding protein (LOC100285404), polypyrimidine tract binding protein 1 (Ptbp1), polypyrimidine tract binding protein 1a (ptbp1a), polypyrimidine tract binding protein 1 L homeolog (ptbp1.L), polypyrimidine tract-binding protein 1 (PTB1), polypyrimidine tract-binding protein 1 (LOC100061673), AA407203, AL033359, ATPTB1, HNRNP-I, hnrnp-I, HNRNPI, HNRPI, hnrpi, POLYPYRIMIDINE TRACT-BINDING, POLYPYRIMIDINE TRACT-BINDING PROTEIN 1, polypyrimidine tract-binding protein 1, pPTB, PTB, Ptb, ptb, PTB-1, PTB-T, PTB2, PTB3, PTB4, ptbp1, PTBP1, Pybp, Pybp1, Pybp2, T4P13.16, T4P13_16, vgrbp60, wu:fb99f12, zgc:110689Protein level used designations for PTBP1
- 57 kDa RNA-binding protein PPTB-1
- RNA-binding protein
- heterogeneous nuclear ribonucleoprotein I
- heterogeneous nuclear ribonucleoprotein polypeptide I
- hnRNP I
- polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
- polypyrimidine tract-binding protein 1
- polypyrimidine tract binding protein 1
- hnrnp I
- hnRNP I-related RNA transport protein VgRBP60
- polypyrimidine tract-binding protein
- pyrimidine binding protein 1
- pyrimidine binding protein 2
- brb
- brom bones
- PTB
- LOW QUALITY PROTEIN: polypyrimidine tract-binding protein 1
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