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PTAFR Products

(Platelet-Activating Factor Receptor (PTAFR))
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].

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Featured PTAFR Categories

PTAFR Antibodies

High quality antibodies with extensive validation data.

PTAFR ELISA Kits

Reliable ELISA kits for a wide range of species.

PTAFR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PTAFR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (1)
  • (7)
Cat. No. ABIN687127
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7163621
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN1774876
Quantity 50 μg
Datasheet Datasheet

Recommended PTAFR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958630
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958631
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN511480
Quantity 96 tests
Datasheet Datasheet

Recommended PTAFR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7415482
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1330436
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Mammalian Cells
Validations
Cat. No. ABIN7538480
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our PTAFR products

Hammond, Lu, Gelbard: "Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." in: Frontiers in cellular neuroscience, Vol. 9, pp. 505, (2016) (PubMed).

Chen, Lan, Zhang, Dong, Kang, Zhang, Fu, Liu, Liu, Zhang, Hou, Zhan: "Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma." in: Oncogene, Vol. 34, Issue 40, pp. 5114-27, (2015) (PubMed).

Chen, Lan, Zhang, Dong, Kang, Zhang, Fu, Liu, Liu, Zhan: "Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer." in: Cancer research, Vol. 75, Issue 19, pp. 4198-210, (2015) (PubMed).

Synonyms and alternative names related to PTAFR

platelet activating factor receptor (PTAFR), platelet-activating factor receptor (Ptafr), platelet activating factor receptor L homeolog (ptafr.L), platelet activating factor receptor (ptafr), platelet activating factor receptor (Ptafr), platelet-activating factor receptor (PTAFR), MGC52896, MGC160177, PAF-R, PAFR, PAFr, pafr

Protein level used designations for PTAFR

  • PAF-R
  • PAFr
  • platelet-activating factor receptor
  • PAF receptor
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