PTAFR Products
(Platelet-Activating Factor Receptor (PTAFR))
Categories
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
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Featured PTAFR Categories
PTAFR Antibodies
High quality antibodies with extensive validation data.
PTAFR ELISA Kits
Reliable ELISA kits for a wide range of species.
PTAFR Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTAFR Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (1)
- (7)
Cat. No.
ABIN687127
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7163621
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN1774876
Quantity
50 μg
Datasheet
Datasheet
Recommended PTAFR ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958630
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958631
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN511480
Quantity
96 tests
Datasheet
Datasheet
Recommended PTAFR Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7415482
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN1330436
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
Cat. No.
ABIN7538480
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our PTAFR products
: "Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." in: Frontiers in cellular neuroscience, Vol. 9, pp. 505, (2016) (PubMed).: "Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma." in: Oncogene, Vol. 34, Issue 40, pp. 5114-27, (2015) (PubMed).
: "Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer." in: Cancer research, Vol. 75, Issue 19, pp. 4198-210, (2015) (PubMed).
Synonyms and alternative names related to PTAFR
platelet activating factor receptor (PTAFR), platelet-activating factor receptor (Ptafr), platelet activating factor receptor L homeolog (ptafr.L), platelet activating factor receptor (ptafr), platelet activating factor receptor (Ptafr), platelet-activating factor receptor (PTAFR), MGC52896, MGC160177, PAF-R, PAFR, PAFr, pafrProtein level used designations for PTAFR
- PAF-R
- PAFr
- platelet-activating factor receptor
- PAF receptor
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