PSME3 Products
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
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Featured PSME3 Categories
PSME3 Antibodies
High quality antibodies with extensive validation data.
PSME3 ELISA Kits
Reliable ELISA kits for a wide range of species.
PSME3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSME3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7441328
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (6)
Cat. No.
ABIN2856424
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (4)
Cat. No.
ABIN7164919
Quantity
100 μg
Datasheet
Datasheet
Recommended PSME3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958989
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1150397
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Validations
Cat. No.
ABIN1150398
Quantity
96 tests
Datasheet
Datasheet
Recommended PSME3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124706
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124704
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7279625
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PSME3 products
: "REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway." in: Nature communications, Vol. 6, pp. 6875, (2015) (PubMed).: "PA28γ is a novel corepressor of HTLV-1 replication and controls viral latency." in: Blood, Vol. 121, Issue 5, pp. 791-800, (2013) (PubMed).
: "Relationships between autoantibody responses to deletion mutants of Ki antigen and clinical manifestations of lupus." in: The Journal of rheumatology, Vol. 30, Issue 6, pp. 1208-14, (2003) (PubMed).
: "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 10, pp. 4923-35, (1998) (PubMed).
Synonyms and alternative names related to PSME3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) (Psme3), proteasome activator subunit 3 (Psme3), proteasome activator subunit 3 (PSME3), proteasome activator subunit 3 S homeolog (psme3.S), AA410043, Ab2-371, AU020960, Ki, PA28-gamma, pa28g, PA28G, PA28gamma, psme3b, REG-GAMMA, REGgammaProtein level used designations for PSME3
- 11S regulator complex subunit gamma
- REG-gamma
- activator of multicatalytic protease subunit 3
- ki nuclear autoantigen
- proteaseome (prosome, macropain) 28 subunit, 3
- proteasome activator 28 subunit gamma
- proteasome activator complex subunit 3
- 11S regulator complex gamma subunit
- Ki antigen
- Ki nuclear autoantigen
- PA28 gamma variant 5
- proteasome activator 28-gamma
- PA28g
- PA28gamma
- proteasome activator subunit 3
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