PSME2 Products
(Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))
Categories
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008].
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Featured PSME2 Categories
PSME2 Antibodies
High quality antibodies with extensive validation data.
PSME2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSME2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IP
Validations
- (6)
Cat. No.
ABIN562499
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN390645
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN390646
Quantity
400 μL
Datasheet
Datasheet
Recommended PSME2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951635
Quantity
96 tests
Datasheet
Datasheet
Recommended PSME2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124619
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316663
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316665
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PSME2 products
: "Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration." in: Nature communications, Vol. 9, Issue 1, pp. 1738, (2018) (PubMed).: "Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28." in: Arthritis and rheumatism, Vol. 54, Issue 7, pp. 2175-83, (2006) (PubMed).
: "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs." in: The Journal of cell biology, Vol. 141, Issue 7, pp. 1489-502, (1998) (PubMed).
Synonyms and alternative names related to PSME2
proteasome activator subunit 2 (psme2), proteasome activator subunit 2 (PSME2), proteasome activator subunit 2 (Psme2), proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), AA589371, AI788882, PA28B, PA28b, PA28beta, REGbeta, unp309Protein level used designations for PSME2
- proteasome activator complex subunit 2
- pA28-b
- proteasome activator subunit 2
- 11S regulator complex subunit beta
- PA28b
- PA28beta
- REG-beta
- activator of multicatalytic protease subunit 2
- protease (prosome, macropain) 28 subunit, beta
- proteasome (prosome, macropain) 28 subunit, beta
- proteasome activator 28 subunit beta
- 11S regulator complex beta subunit
- MCP activator, 31-kD subunit
- cell migration-inducing protein 22
- proteasome activator 28-beta
- proteasome activator hPA28 subunit beta
- PA28 beta subunit
- proteasome activator 28 beta subunit
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