PSME1 Products
(Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured PSME1 Categories
PSME1 Antibodies
High quality antibodies with extensive validation data.
PSME1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSME1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IP
Validations
- (4)
Cat. No.
ABIN7164913
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN651448
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN519415
Quantity
50 μg
Datasheet
Datasheet
Recommended PSME1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975639
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951630
Quantity
96 tests
Datasheet
Datasheet
Recommended PSME1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124618
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316661
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2131393
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our PSME1 products
: "Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells." in: The Journal of experimental medicine, Vol. 212, Issue 5, pp. 743-57, (2015) (PubMed).: "Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma." in: Blood, Vol. 117, Issue 24, pp. 6638-49, (2011) (PubMed).
: "Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28." in: Arthritis and rheumatism, Vol. 54, Issue 7, pp. 2175-83, (2006) (PubMed).
Synonyms and alternative names related to PSME1
proteasome activator subunit 1 (psme1), proteasome activator subunit 1 (PSME1), proteasome activator subunit 1 (Psme1), proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) (Psme1), AW413925, fk89d05, IFI5111, PA28A, PA28a, PA28alpha, REGalpha, wu:fk89d05Protein level used designations for PSME1
- proteasome activator complex subunit 1
- pA23-a
- proteasome activator subunit 1
- 11S regulator complex subunit alpha
- PA28a
- PA28alpha
- REG-alpha
- activator of multicatalytic protease subunit 1
- protease (prosome, macropain) 28 subunit, alpha
- proteasome (prosome, macropain) 28 subunit, alpha
- proteasome activator 28 subunit alpha
- 29-kD MCP activator subunit
- IGUP I-5111
- interferon gamma up-regulated I-5111 protein
- interferon-gamma IEF SSP 5111
- interferon-gamma-inducible protein 5111
- PA28 alpha subunit
- proteasome activator 28 alpha subunit
- proteasome activator PA28 alpha subunit
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