PSMD4/ASF Products
(Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4))
Categories
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008].
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Featured PSMD4/ASF Categories
PSMD4/ASF Antibodies
High quality antibodies with extensive validation data.
PSMD4/ASF ELISA Kits
Reliable ELISA kits for a wide range of species.
PSMD4/ASF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSMD4/ASF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN3021330
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7142212
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN519398
Quantity
100 μg
Datasheet
Datasheet
Recommended PSMD4/ASF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969691
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975602
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN778103
Quantity
96 tests
Datasheet
Datasheet
Recommended PSMD4/ASF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316639
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316641
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN1343997
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PSMD4/ASF products
: "Glatiramer acetate and nanny proteins restrict access of the multiple sclerosis autoantigen myelin basic protein to the 26S proteasome." in: BioMed research international, Vol. 2014, pp. 926394, (2014) (PubMed).: "Functional differences between two major ubiquitin receptors in the proteasome; S5a and hRpn13." in: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 425-8, (2010) (PubMed).
: "Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1424-34, (2010) (PubMed).
: "Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13." in: Molecular cell, Vol. 35, Issue 3, pp. 280-90, (2009) (PubMed).
: "S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains." in: The EMBO journal, Vol. 28, Issue 13, pp. 1867-77, (2009) (PubMed).
: "The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor." in: Current pharmaceutical design, Vol. 15, Issue 17, pp. 1937-48, (2009) (PubMed).
: "Age-related modifications of egr1 expression and ubiquitin-proteasome components in pet dog hippocampus." in: Mechanisms of ageing and development, Vol. 130, Issue 5, pp. 320-7, (2009) (PubMed).
: "Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a." in: Biochemistry, Vol. 41, Issue 6, pp. 1767-77, (2002) (PubMed).
: "Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14336-45, (2000) (PubMed).
: "Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes." in: The EMBO journal, Vol. 19, Issue 15, pp. 4144-53, (2000) (PubMed).
Synonyms and alternative names related to PSMD4/ASF
proteasome 26S subunit, non-ATPase 4 (psmd4), proteasome 26S subunit, non-ATPase 4 (PSMD4), 26S proteasome non-ATPase regulatory subunit 4 (LOC100194679), 26S proteasome non-ATPase regulatory subunit 4 (psmD4), 26S proteasome non-ATPase regulatory subunit 4 (LOC100283637), 26s proteasome non-atpase regulatory subunit 4 (26s proteasomeregulatory subunit s5a) (Smp_000740.1), proteasome 26S subunit, non-ATPase 4 L homeolog (psmd4.L), proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (Psmd4), proteasome 26S subunit, non-ATPase 4 (Psmd4), proteasome 26S subunit, non-ATPase 4b (psmd4b), AF, af-1, AF-1, Af1, angiocidin, ASF, DDBDRAFT_0202512, DDBDRAFT_0232981, DDB_0202512, DDB_0232981, im:6912672, mcb1, MCB1, Mcb1, PSMD4, psmd4, pub-r5, pUB-R5, rpn10, Rpn10, S5A, wu:fc68c04, xrpn10c, zgc:110247Protein level used designations for PSMD4/ASF
- proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
- anti-secretory factor
- 26S proteasome non-ATPase regulatory subunit 4
- 26S proteasome subunit
- 26S proteasome regulatory subunit S5A
- type A von Willebrand factor domain-containing protein
- ubiquitin interacting motif domain-containing protein
- proteasome 26S subunit, non-ATPase, 4
- RPN10 homolog
- S5a/antisecretory factor protein
- angiocidin
- antisecretory factor 1
- multiubiquitin chain-binding protein
- proteasome 26S subunit non-ATPase 4
- 26S proteasome regulatory subunit RPN10
- proteasome 26S non-ATPase subunit 4
- anti secretory factor 1
- multiubiquitin-chain-binding protein
- antisecretory factor
- psmd4l
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