PSMC5 Products
(Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
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Featured PSMC5 Categories
PSMC5 Antibodies
High quality antibodies with extensive validation data.
PSMC5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSMC5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC (p), ICC
Validations
- (5)
Cat. No.
ABIN2856087
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN3022098
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC, IP
Validations
- (4)
Cat. No.
ABIN2780449
Quantity
100 μL
Datasheet
Datasheet
Recommended PSMC5 Proteins
Latest Publications for our PSMC5 products
: "Human Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity." in: Journal of cellular physiology, (2016) (PubMed).: "Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91200, (2014) (PubMed).
: "Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor." in: The Biochemical journal, Vol. 458, Issue 1, pp. 95-107, (2014) (PubMed).
: "The 26S proteasome drives trinucleotide repeat expansions." in: Nucleic acids research, Vol. 41, Issue 12, pp. 6098-108, (2013) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
: "Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 5837-50, (2008) (PubMed).
Synonyms and alternative names related to PSMC5
protease (prosome, macropain) 26S subunit, ATPase 5 (Psmc5), proteasome 26S subunit, ATPase 5 (PSMC5), proteasome 26S subunit, ATPase 5 (psmc5), proteasome 26S subunit, ATPase 5 L homeolog (psmc5.L), proteasome 26S subunit, ATPase 5 (Psmc5), proteasome 26S subunit, ATPase 5 S homeolog (psmc5.S), mSUG1, p45, p45/SUG, PSMC5, S8, SUG-1, sug-1, SUG1, sug1, Sug1, TBP10, tbp10, TRIP1, wu:fa14g03, wu:fb23a11, xsug1, zgc:92464Protein level used designations for PSMC5
- 26S protease regulatory subunit 8
- 26S proteasome AAA-ATPase subunit RPT6
- p45/SUG
- proteasome 26S subunit ATPase 5
- proteasome subunit p45
- MSUG1 protein
- Tat-binding protein homolog 10
- proteasome 26S ATPase subunit 5
- thyroid hormone receptor-interacting protein 1
- thyroid receptor interactor 1
- TRIP1
- for proteasomal ATPase (SUG1)
- peptidase (prosome, macropain) 26S subunit, ATPase 5
- protease (prosome, macropain) 26S subunit, ATPase 5
- proteasomal ATPase (SUG1)
- proteasome p45/SUG
- 26S protease subunit
- TAT-binding protein homolog 10
- SUG1 homolog
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