PSMB8 Products
(Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
Categories
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified\; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008].
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Featured PSMB8 Categories
PSMB8 Antibodies
High quality antibodies with extensive validation data.
PSMB8 ELISA Kits
Reliable ELISA kits for a wide range of species.
PSMB8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSMB8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN969371
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, IF, IHC (p)
Validations
- (1)
- (7)
Cat. No.
ABIN562483
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440236
Quantity
100 μL
Datasheet
Datasheet
Recommended PSMB8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962229
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958899
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958900
Quantity
96 tests
Datasheet
Datasheet
Recommended PSMB8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316595
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316593
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2131388
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PSMB8 products
: "The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation." in: Science advances, Vol. 5, Issue 5, pp. eaau0495, (2020) (PubMed).: "Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis." in: Cellular signalling, Vol. 26, Issue 11, pp. 2358-69, (2014) (PubMed).
: "Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease." in: Cell death and differentiation, Vol. 18, Issue 6, pp. 1071-81, (2011) (PubMed).
: "PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis." in: Respiratory medicine, Vol. 104, Issue 6, pp. 889-94, (2010) (PubMed).
: "Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells." in: Neoplasia (New York, N.Y.), Vol. 12, Issue 7, pp. 550-61, (2010) (PubMed).
: "The early marginal zone B cell-initiated T-independent type 2 response resists the proteasome inhibitor bortezomib." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 9, pp. 5637-47, (2010) (PubMed).
: "Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma." in: Genes, chromosomes & cancer, Vol. 48, Issue 5, pp. 410-8, (2009) (PubMed).
: "Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer." in: The Journal of infectious diseases, Vol. 197, Issue 3, pp. 371-81, (2008) (PubMed).
: "Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 2, pp. 768-78, (2000) (PubMed).
Synonyms and alternative names related to PSMB8
proteasome subunit beta 8 (PSMB8), proteasome subunit beta 8A (psmb8a), proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8), proteasome subunit beta 8 (Psmb8), ALDD, ATP6V0D2, D6S216, D6S216E, JMP, Lmp-7, LMP7, lmp7, Lmp7, macropain, NKJO, prosome, PSMB5i, RING10, Ring10Protein level used designations for PSMB8
- large multifunctional peptidase 7
- low molecular mass protein 7
- low molecular weight protein 7
- macropain subunit C13
- multicatalytic endopeptidase complex subunit C13
- protease component C13
- proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
- proteasome catalytic subunit 3i
- proteasome component C13
- proteasome subunit Y2
- proteasome subunit beta 5i
- proteasome subunit beta type-8
- proteasome-related gene 7
- really interesting new gene 10 protein
- MHC class II DO beta
- proteasome subunit beta-5i
- proteasome (prosome, macropain) subunit, beta type, 8
- large multifunctional protease 7
- proteosome (prosome, macropain) subunit, beta type 8
- MC13 (LMP7)
- proteasome subunit MC13
- proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
- proteosome beta 8 subunit
- low molecular mass polypeptide 7
- proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
- proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)
- proteasome beta 8 subunit
- proteasome subunit LMP7
- macropain
- proteasome subunit, beta type 8
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