PSMA Products
(Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
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This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010].
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Featured PSMA Categories
PSMA Antibodies
High quality antibodies with extensive validation data.
PSMA ELISA Kits
Reliable ELISA kits for a wide range of species.
PSMA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PSMA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Pig, Rat
Application
WB, IHC (p), ICC
Validations
- (9)
- (8)
Cat. No.
ABIN1302364
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (6)
Cat. No.
ABIN7234408
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7443569
Quantity
100 μL
Datasheet
Datasheet
Recommended PSMA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6975679
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962642
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951666
Quantity
96 tests
Datasheet
Datasheet
Recommended PSMA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275493
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275491
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275488
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PSMA products
: "Prostate-Specific Membrane Antigen in Anaplastic and Poorly Differentiated Thyroid Cancer-A New Diagnostic and Therapeutic Target?" in: Cancers, Vol. 13, Issue 22, (2021) (PubMed).: "Prostate specific membrane antigen (PSMA) in urothelial cell carcinoma (UCC) is associated with tumor grading and staging." in: Journal of cancer research and clinical oncology, (2020) (PubMed).
: "Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions." in: PLoS ONE, Vol. 14, Issue 1, pp. e0210297, (2019) (PubMed).
: "Heterogeneous PSMA expression on circulating tumor cells: a potential basis for stratification and monitoring of PSMA-directed therapies in prostate cancer." in: Oncotarget, Vol. 7, Issue 23, pp. 34930-41, (2018) (PubMed).
: "Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury." in: Journal of neurochemistry, Vol. 134, Issue 2, pp. 340-53, (2015) (PubMed).
: "Automated multiplexed ECL Immunoarrays for cancer biomarker proteins." in: Analytical chemistry, Vol. 87, Issue 8, pp. 4472-8, (2015) (PubMed).
: "Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA)." in: The Prostate, Vol. 74, Issue 16, pp. 1674-90, (2014) (PubMed).
: "Flexible gold electrode array for multiplexed immunoelectrochemical measurement of three protein biomarkers for prostate cancer." in: ACS applied materials & interfaces, Vol. 6, Issue 22, pp. 20137-43, (2014) (PubMed).
: "Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction." in: The European journal of neuroscience, Vol. 37, Issue 1, pp. 118-29, (2013) (PubMed).
: "Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes." in: Scientific reports, Vol. 2, pp. 706, (2012) (PubMed).
Synonyms and alternative names related to PSMA
putative N-acetylated-alpha-linked acidic dipeptidase (LOC451185), folate hydrolase 1B (FOLH1B), folate hydrolase 1 (FOLH1), folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), folate hydrolase 1 (Folh1), FGCP, FOLH, GCP2, GCPII, mGCP, mopsm, Naalad, NAALAD1, NAALAdase, PSM, PSMAProtein level used designations for PSMA
- folate hydrolase 1
- glutamate carboxypeptidase 2
- folate hydrolase (prostate-specific membrane antigen) 1
- glutamate carboxypeptidase 2-like
- N-acetylated alpha-linked acidic dipeptidase 1
- N-acetylated-alpha-linked acidic dipeptidase I
- NAALADase I
- cell growth-inhibiting gene 27 protein
- folylpoly-gamma-glutamate carboxypeptidase
- glutamate carboxylase II
- glutamate carboxypeptidase II
- membrane glutamate carboxypeptidase
- prostate specific membrane antigen variant F
- pteroylpoly-gamma-glutamate carboxypeptidase
- FGCP
- GCPII
- mGCP
- prostate-specific membrane antigen homolog
- prostate-specific membrane antigen
- N-acetylated alpha-linked acidic dipeptidase
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