NOG Protein
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- Target See all NOG Proteins
- NOG (Noggin (NOG))
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCS
- Characteristics
- Fully biologically active when compared to standard. The ED50 determined by inhibiting BMP-4-induced alkaline phosphatase production ofmurine ATDC5 cells is less than 80 ng/ml, corresponding to a specific activity of >1.3×104 IU/mg in the presence of 5ng/ml BMP-4.
- Purity
- > 95 % by SDS-PAGE and HPLC analyses.
- Endotoxin Level
- Level Less than 1EU/µg of rHu NOGGIN as determined by LAL method
- Top Product
- Discover our top product NOG Protein
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Noggin (NOG) (AA 20-232) (Active) protein
NOG Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) (AA 28-232) (Active) proteinNOG Origin: Human Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) proteinNOG Origin: Human Host: CHO Cells Recombinant > 95% as determined by Tris-Bis PAGE
Noggin (NOG) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) protein (His tag)NOG Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (His tag)NOG Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Noggin (NOG) (AA 28-232) protein (GST tag)NOG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Noggin (NOG) (AA 28-232) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
- Storage
- 4 °C
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- Target
- NOG (Noggin (NOG))
- Alternative Name
- NOGGIN (NOG Products)
- Synonyms
- SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
- Background
- Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Synonym: NOGGIN, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.
- Molecular Weight
- Approximately 46.2 kDa non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
- Pathways
- Stem Cell Maintenance, Tube Formation
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