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MICB Protein

MICB Origin: Human Host: Escherichia coli (E. coli) > 95 % by SDS-PAGE and HPLC analyses. ELISA Active
Catalog No. ABIN988150
  • Target See all MICB Proteins
    MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
    Biological Activity
    Active
    Origin
    Human
    Source
    • 8
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    ELISA
    Characteristics
    Measured by its ability to bind MICB antibody in a ELISA.
    Purity
    > 95 % by SDS-PAGE and HPLC analyses.
    Endotoxin Level
    Level Less than 1EU/µg of rHuMIC-B as determined by LAL method
    Top Product
    Discover our top product MICB Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
    Storage
    4 °C
  • Target
    MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
    Alternative Name
    MIC-B (MICB Products)
    Synonyms
    PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
    Background
    MIC-B (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MIC-A, shares 85% amino acid identity with MIC-B. These 2 proteins are distantly related to the MHC class I proteins. MIC-A and MIC-B (MIC-A/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding MIC-A/B are found within the major histocompatibility complex on human chromosome 6. The MIC-B locus is polymorphic with more than 15 recognized human alleles. MIC-A/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MIC-A/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ abeta T cells. Recognition of MIC-A/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MIC-A/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MIC-A/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
    Molecular Weight
    Approximately 37 kDa, 326 amino acid residues containing the extracellular domain of mature human MICB (amino acid residues Ala23 – Tyr312).100µg /1000µg
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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