CCL7 Protein

Catalog No. ABIN988136

Product Details

Target: CCL7 (Chemokine (C-C Motif) Ligand 7 (CCL7))

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPK

Characteristics: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 80 ng/ml, corresponding to a specific activity of >, 1.3 × 104 IU/mg.

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: Level Less than 1EU/µg of rHuMCP-3/CCL7 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: CCL7 (Chemokine (C-C Motif) Ligand 7 (CCL7))

Alternative Name: MCP-3/CCL7 (CCL7 Products)

Synonyms: CCL7 Protein, FIC Protein, MARC Protein, MCP-3 Protein, MCP3 Protein, NC28 Protein, SCYA6 Protein, SCYA7 Protein, Scya7 Protein, fic Protein, marc Protein, mcp3 Protein, C-C motif chemokine ligand 7 Protein, chemokine (C-C motif) ligand 7 Protein, CCL7 Protein, Ccl7 Protein

Background: MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP2.Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils. Synonym: MCP-3/CCL7, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4,150mM NaCl.

Molecular Weight: 9.0 kDa, a single, non-glycosylated polypeptide chain containing 76 amino acids.