Growth Hormone 1 Protein (GH1)

Catalog No. ABIN987903

Product Details

Target: Growth Hormone 1 (GH1)

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG

Characteristics: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0×107 IU/mg.

Purity: > 96 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: Level Less than 1EU/µg of rHuGH as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: Growth Hormone 1 (GH1)

Alternative Name: Growth Hormone (GH) (GH1 Products)

Synonyms: GH Protein, GH-N Protein, GHN Protein, IGHD1B Protein, hGH-N Protein, Gh1 Protein, GH1 Protein, gh Protein, Gh Protein, GH2 Protein, RNGHGP Protein, ghl Protein, gh-n Protein, ghn Protein, ighd1b Protein, gh1 Protein, ghb-A Protein, GHI Protein, GHB3 Protein, growth hormone 1 Protein, growth hormone Protein, somatotropin-like Protein, somatotropin Protein, growth hormone prepeptide Protein, growth hormone 1 L homeolog Protein, growth hormone 1 S homeolog Protein, Somatotropin-1 Protein, GH1 Protein, Gh Protein, GH Protein, LOC100305005 Protein, Gh1 Protein, LOC100534452 Protein, LOC100232594 Protein, LOC100303681 Protein, gh1 Protein, LOC100356068 Protein, LOC100136588 Protein, gh1.L Protein, gh1.S Protein, LOC109081196 Protein

Background: Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin.4 The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified. Synonym: Growth Hormone (GH), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution with 5mM NaHCO3, pH 7.0.

Molecular Weight: Approximately 22 kDa, a single non-glycosylated polypeptide chain containing 191 amino acids

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process