FGF7 Protein

Catalog No. ABIN987850

Product Details

Target: FGF7 (Fibroblast Growth Factor 7 (FGF7))

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAI

Characteristics: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using monkey 4MBr-5 cells is less than 75 ng/ml, corresponding to a specific activity of >, 1.3 × 104 IU/mg.

Purity: > 96 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: Level Less than 1EU/µg of rHuFGF-7/KGF-1 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: FGF7 (Fibroblast Growth Factor 7 (FGF7))

Alternative Name: Fibrobalst Growth Factor-7 (FGF-7) (FGF7 Products)

Synonyms: HBGF-7 Protein, KGF Protein, Kgf Protein, kgf Protein, FGF-7 Protein, fgf7 Protein, fibroblast growth factor 7 Protein, fibroblast growth factor 7 L homeolog Protein, FGF7 Protein, Fgf7 Protein, fgf7 Protein, fgf7.L Protein

Background: Keratinocyte Growth Factor-1 (KGF-1/FGF-7) is one of 23 known members of the FGF family. All FGFs have two conserved cysteine residues and share 30 - 50% sequence identity at the amino acid level. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF-1/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF-1/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing. Synonym: Fibroblast Growth Factor-7 ( FGF-7), Human. Formulation: Lyophilized from a 0.2µm filtered solution in 20mM PB, pH 8.0, 1M NaCl.

Molecular Weight: Approximately 19.0 kDa, a single, non-glycosylated polypeptide chain containing 164 amino acids.

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway