BMP7 Protein

Catalog No. ABIN987784

Product Details

Target: BMP7 (Bone Morphogenetic Protein 7 (BMP7))

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: Level Less than 1EU/µg of rHuBMP-7 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at Applications 1. Molecular standard (Western, ELISA) in studying secreted BMP-7,2. Preparing antibodies for BMP-7 monomer, 3. Molecule standard in detecting secreted BMP-7 in reduced SDS-PAGE.

Storage: 4 °C

Target Details

Target: BMP7 (Bone Morphogenetic Protein 7 (BMP7))

Alternative Name: Bone Morphogenetic Protein-7 (BMP-7) (BMP7 Products)

Synonyms: bmp-7 Protein, bmp7 Protein, op-1 Protein, BMP7 Protein, zgc:153025 Protein, OP-1 Protein, OP1 Protein, BMP-7 Protein, fb83f09 Protein, wu:fb83f09 Protein, bone morphogenetic protein 7 Protein, bone morphogenetic protein 7, gene 1 L homeolog Protein, bone morphogenetic protein 7b Protein, bone morphogenetic protein 7, gene 2 L homeolog Protein, bone morphogenetic protein 7a Protein, BMP7 Protein, bmp7.1.L Protein, LOC100136282 Protein, bmp7b Protein, Bmp7 Protein, LOC100008826 Protein, bmp7.2.L Protein, bmp7a Protein

Background: Human BMP-7 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP-7 is synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. Synonym: Bone Morphogenetic Protein-7 (BMP-7), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.

Molecular Weight: Approximately 15.6 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids.

Pathways: Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance