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Defensin beta 4 Protein (DEFB4) (AA 33-47)

DEFB4 Origin: Human Host: Escherichia coli (E. coli) > 98 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN987775
  • Target See all Defensin beta 4 (DEFB4) Proteins
    Defensin beta 4 (DEFB4)
    Biological Activity
    Active
    Protein Characteristics
    AA 33-47
    Origin
    • 6
    • 2
    • 1
    Human
    Source
    • 4
    • 2
    • 2
    Escherichia coli (E. coli)
    Sequence
    EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTK
    Characteristics
    Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usinghuman monocytes is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.
    Purity
    > 98 % by SDS-PAGE and HPLC analyses.
    Endotoxin Level
    Level Less than 1EU/µg of rHuBD-4 as determined by LAL method
    Top Product
    Discover our top product DEFB4 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
    Storage
    4 °C
  • Target
    Defensin beta 4 (DEFB4)
    Alternative Name
    beta-Defensin 4 (BD-4) (DEFB4 Products)
    Synonyms
    BD-2 Protein, DEFB-2 Protein, DEFB102 Protein, DEFB2 Protein, DEFB4 Protein, HBD-2 Protein, SAP1 Protein, 2310001F05Rik Protein, BD-4 Protein, Defb2 Protein, Defb3 Protein, BNBD-4 Protein, BNBD4 Protein, defensin beta 4A Protein, defensin beta 4 Protein, defensin, beta 4A Protein, DEFB4A Protein, Defb4 Protein
    Background
    Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Synonym: beta-Defensin 4 ( BD-4 ), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
    Molecular Weight
    Approximately 6.0 KDa, a single non-glycosylated polypeptide chain containing 50 amino acids.
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