Angiostatin Protein (ANG)
ANG
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % by SDS-PAGE and HPLC analyses.
Active
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- Target See all Angiostatin (ANG) Proteins
- Angiostatin (ANG)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSS
- Characteristics
- Fully biologically active when compared to standard. The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×105 Units/mg.
- Purity
- > 95 % by SDS-PAGE and HPLC analyses.
- Endotoxin Level
- Level Less than 1EU/µg of rHuAngiostatin as determined by LAL method
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
- Storage
- 4 °C
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- Target
- Angiostatin (ANG)
- Alternative Name
- Angiostatin K1-3 (ANG Products)
- Synonyms
- ALS9 Protein, HEL168 Protein, RNASE4 Protein, RNASE5 Protein, LPA Protein, AI649309 Protein, Pg Protein, Ab1-346 Protein, AI385586 Protein, Ang1 Protein, Rnase5 Protein, Rnase5a Protein, angiogenin Protein, plasminogen Protein, angiogenin, ribonuclease, RNase A family, 5 Protein, ANG Protein, PLG Protein, Plg Protein, Ang Protein
- Background
- Angiostatin K1-3 is a ~30 kDa fragment of plasminogen that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Recombinant angiostatin is expressed in E. coli. Synonym: Angiostatin K1-3, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM NaAc, pH5.5, 4% mannitol.
- Molecular Weight
- Approximately 30.0 KDa, a single non-glycosylated polypeptide chain containing 259 amino acids.
- Pathways
- Lipid Metabolism
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