TIMP1 Protein
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- Target See all TIMP1 Proteins
- TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA
- Characteristics
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Purified recombinant Human TIMP1 protein
Expression System: E.coli
Bioactivity: TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 µg/mL, when using an MMP-1 concentration of 1.6 µg/mL. - Purity
- > 95 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product TIMP1 Protein
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TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 24-207) protein (Fc Tag)
TIMP1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 25-205) protein (Fc Tag)TIMP1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 1-169) protein (GST tag)TIMP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
TIMP Metallopeptidase Inhibitor 1 (TIMP1) proteinTIMP1 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (Active) proteinTIMP1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (Active) proteinTIMP1 Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
- Alternative Name
- TIMP1 (TIMP1 Products)
- Synonyms
- TIMP-1 Protein, TIMP1 Protein, DKFZp468A0912 Protein, CLGI Protein, EPA Protein, EPO Protein, HCI Protein, TIMP Protein, Timp Protein, Clgi Protein, TIMP metallopeptidase inhibitor 1 Protein, tissue inhibitor of metalloproteinase 1 Protein, TIMP1 Protein, Timp1 Protein
- Background
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TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors.
Alternative Names: TIMP 1 protein, TIMP-1 protein, TIMP-1, Tissue inhibitor of metalloproteinases: Fibroblast collagenase inhibitor, Erythroid-potentiating activity protein, TIMP1, TIMP 1, TIMP-1 protein - Molecular Weight
- 20.6 kDa
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