SFRP1 Protein
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- Target See all SFRP1 Proteins
- SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HeLa Cells
- Sequence
- SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
- Characteristics
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Purified recombinant Human sFRP1 protein
Expression System: HeLa cells
Bioactivity: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5 µg/mL. - Purity
- > 97 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product SFRP1 Protein
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Secreted Frizzled-Related Protein 1 (SFRP1) (AA 32-314) protein (His tag)
SFRP1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Secreted Frizzled-Related Protein 1 (SFRP1) (AA 1-314) protein (GST tag)SFRP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Secreted Frizzled-Related Protein 1 (SFRP1) proteinSFRP1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))
- Alternative Name
- sFRP1 (SFRP1 Products)
- Background
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Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas.
Alternative Names: SFRP-1 protein, Secreted Frizzled Related Protein 1 protein, sFRP-1 protein, sFRP 1, sFRP 1 protein, Secreted Apoptosis Related Protein-2 protein, sFRP-1, sFRP1, Soluble Frizzled Related Protein-1 protein, SARP-2 protein - Pathways
- WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of fat Cell Differentiation
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