Platelet-Derived Growth Factor CC (PDGFCC) (Active) Protein
PDGFCC
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 98 % pure
Active
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- Target See all Platelet-Derived Growth Factor CC (PDGFCC) Proteins
- Platelet-Derived Growth Factor CC (PDGFCC)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Origin
- Human
- Source
- Escherichia coli (E. coli)
- Sequence
- MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG
- Characteristics
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Purified recombinant Human PDGF CC protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/mL. - Purity
- > 98 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- Platelet-Derived Growth Factor CC (PDGFCC)
- Alternative Name
- PDGF CC (PDGFCC Products)
- Synonyms
- 1110064L01Rik Protein, AI647969 Protein, PDGF-C Protein, SCDGF Protein, platelet-derived growth factor, C polypeptide Protein, platelet derived growth factor C Protein, Pdgfc Protein
- Background
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The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells.
Alternative Names: Osteosarcoma-derived Growth Factor protein, Platelet-Derived Growth Factor-CC protein, ODGF protein, Glioma-derived growth factor protein, PCGF protein, GDGF protein
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