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IGFBP4 Protein

IGFBP4 Origin: Human Host: Hi-5 Cells Recombinant > 95 % pure Active
Catalog No. ABIN935568
  • Target See all IGFBP4 Proteins
    IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Source
    • 15
    • 3
    • 3
    • 2
    • 1
    • 1
    Hi-5 Cells
    Sequence
    DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
    Characteristics
    Purified recombinant Human IGF BP4 protein
    Expression System: Hi-5 cells
    Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
    Purity
    > 95 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
    Top Product
    Discover our top product IGFBP4 Protein
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Comment

    Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    RT/-20 °C
  • Target
    IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
    Alternative Name
    IGF BP4 (IGFBP4 Products)
    Synonyms
    IGFBP4 Protein, igfbp4 Protein, BP-4 Protein, HT29-IGFBP Protein, IBP4 Protein, IGFBP-4 Protein, AI875747 Protein, Deb2 Protein, IGF-BP4 Protein, IBP-4 Protein, insulin like growth factor binding protein 4 Protein, insulin-like growth factor-binding protein 4 Protein, insulin-like growth factor binding protein 4 Protein, IGFBP4 Protein, LOC100136305 Protein, LOC100194498 Protein, igfbp4 Protein, Igfbp4 Protein
    Background
    IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF1ndependent pathway.
    Alternative Names: Insulin-like Growth Factor-Binding Protein 4 protein, IGF BP-4, IGF BP 4 protein, IBP-4 protein, IGF BP4, colon cancer cell growth inhibitor protein, IGF BP-4 protein, HT29-IGF-BP protein, IGF BP-4 protein, IGF BP 4
    Molecular Weight
    25.8 kDa
    Pathways
    WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
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