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HBEGF Protein

HBEGF Origin: Human Host: Insect cells (Sf9) Recombinant
Catalog No. ABIN935466
  • Target See all HBEGF Proteins
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Protein Type
    Recombinant
    Origin
    • 7
    • 4
    • 3
    • 1
    Human
    Source
    • 7
    • 4
    • 2
    • 1
    • 1
    Insect cells (Sf9)
    Characteristics
    Purified recombinant Human HB-EGF protein
    Expression System: Spodoptera frugiperda
    Endotoxin Level
    < 1.0 EU per 1 µg of the protein by the LAL method.
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    Discover our top product HBEGF Protein
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    RT/-20 °C
  • Target
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Alternative Name
    HB-EGF (HBEGF Products)
    Background
    HBEGF was originally purified based on its heparinbinding property and mitogenic activity on BALB3T3 fibroblasts from the conditioned medium of the human U937 histiocytic lymphoma cell line. The natural protein has an apparent molecular mass of 19 23 kDa and exists in multiple forms as a result of heterogenous Oglycosylation and/or Nterminal truncation. In addition to fibroblasts, HB EGF is also a potent mitogen for keratinocytes and smooth muscle cells but not for capillary endothelial cells. HBEGF is produced in monocytes and macrophages. In addition, transcription of HBEGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells (SMC), suggesting that HB EGF may have an important role in the pathogenesis of atherosclerosis.
    Alternative Names: Heparin Binding Epidermal Growth Factor protein, HB EGF protein
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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