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DLL4 Protein

DLL4 Origin: Human Host: HEK-293T Cells Recombinant > 95 % pure Active
Catalog No. ABIN935314
  • Target See all DLL4 Proteins
    DLL4 (delta-Like 4 (DLL4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 9
    • 4
    • 3
    Human
    Source
    • 9
    • 5
    • 1
    • 1
    HEK-293T Cells
    Sequence
    SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP
    Characteristics
    Purified recombinant Human sDLL4 protein
    Expression System: 293 cells
    Bioactivity: The sDLL-4, when immobilized at concentrations >1.5 µg/mL will inhibit myogenesis in C2C12 cells.
    Purity
    > 95 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
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  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    RT/-20 °C
  • Target
    DLL4 (delta-Like 4 (DLL4))
    Alternative Name
    sDLL4 (DLL4 Products)
    Synonyms
    hdelta2 Protein, Delta4 Protein, si:ch211-244p18.5 Protein, zgc:136596 Protein, delta like canonical Notch ligand 4 Protein, delta-like 4 (Drosophila) Protein, DLL4 Protein, Dll4 Protein, dll4 Protein
    Background
    Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth.
    Alternative Names: sDLL-4 protein, sDLL 4 protein, sDLL 4, sDLL4, sDLL-4 protein, Delta-like protein 4, Drosophila Delta homolog 4 protein, sDLL-4
    Molecular Weight
    54 kDa
    Pathways
    Notch Signaling
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