(3 references)-
- Target See all alpha-Thrombin products
- alpha-Thrombin
- Protein Type
- Native
- Biological Activity
- Active
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Origin
- Human
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Source
- Human
- Characteristics
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Purified native Human alpha Thrombin protein
Bioactivity: 4493 units/mg protein- Specific activity is determined by fibrinogen clotting assay relative to human NIH standard thrombin.
Protein Source: Human serum/plasma - Purity
- > 95 % pure
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as a liquid with 50 % Glycerol/H2 O (vol/vol).
- Precaution of Use
- Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Aliquot and store at -20 °C.
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: "Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum." in: ACS omega, Vol. 7, Issue 49, pp. 45215-45230, (2022) (PubMed).
: "Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity." in: Pharmaceuticals (Basel, Switzerland), Vol. 15, Issue 11, (2022) (PubMed).
: "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors." in: ChemMedChem, Vol. 16, Issue 24, pp. 3672-3690, (2022) (PubMed).
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: "Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum." in: ACS omega, Vol. 7, Issue 49, pp. 45215-45230, (2022) (PubMed).
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- Target
- alpha-Thrombin
- Alternative Name
- alpha Thrombin (alpha-Thrombin Products)
- Synonyms
- PT Protein, RPRGL2 Protein, THPH1 Protein, coagulation factor II, thrombin Protein, F2 Protein
- Background
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Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII.
Description: Human serum/plasma.
Alternative Names: Thrombin alpha protein - Molecular Weight
- 36.7 kDa
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