alpha 2 Macroglobulin Protein

Catalog No. ABIN934820

Product Details

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Protein Type: Native

Origin: Human

Source: Human

Characteristics: Purified native Human alpha 2 Macroglobulin protein
Protein Source: Human plasma

Purity: > 95 % pure

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from 30 mM Na0 O4, pH 7.0, with glycine as a stabilizer.

Precaution of Use: Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C.

References

Rahman, Jeng, Singh, Coughlin, Essani, McFadden: "Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L." in: Virology, Vol. 386, Issue 2, pp. 462-8, (2009) (PubMed).

Target Details

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: alpha 2 Macroglobulin (A2M Products)

Synonyms: A2MD Protein, CPAMD5 Protein, FWP007 Protein, S863-7 Protein, A2MAC1 Protein, A2m1 Protein, A2maa Protein, Mam Protein, A2mp Protein, A2M Protein, LOC733429 Protein, endod Protein, cpamd5 Protein, fwp007 Protein, s863-7 Protein, a2mb Protein, endodermin Protein, Alpha-2-M Protein, alpha-2-macroglobulin Protein, pregnancy-zone protein L homeolog Protein, alpha-2-macroglobulin S homeolog Protein, pregnancy zone protein Protein, alpha-2-macroglobulin-like Protein, A2M Protein, A2m Protein, LOC477699 Protein, pzp.L Protein, AZL_c00450 Protein, LOC100349077 Protein, a2m Protein, LOC100061656 Protein, LOC100090399 Protein, a2m.S Protein, LOC100469973 Protein, LOC100595735 Protein, PZP Protein, LOC100353095 Protein, LOC101122940 Protein, LOC101801552 Protein, LOC100911545 Protein

Background: A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. .
Description: Human plasma.
Alternative Names: A2M protein, alpha Macroglobulin 2, S863 7 protein, alpha Macroglobulin-2 protein, alpha 2 Macroglobulin, alpha 2 M protein, alpha Macroglobulin-2, DKFZp779B086 protein, alpha 2M protein, alpha Macroglobulin 2 protein, CPAMD5 protein, FWP007 protein

Molecular Weight: 725 kDa

Pathways: Lipid Metabolism