Factor VII Protein

Catalog No. ABIN934812

Product Details

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Protein Type: Native

Biological Activity: Active

Origin: Human

Source: Human

Characteristics: Purified native Human Factor VII protein
Bioactivity: 3296 units/mg protein - Specific activity is determined by the Factor VII clotting assay. One unit of activity is equivalent to the factor VII activity in one milliliter of normal plasma.
Protein Source: Human serum/plasma

Purity: > 95 % pure

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Buffer: 50 % Glycerol/H2 O (vol/vol).

Precaution of Use: Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C.

Target Details

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Alternative Name: Factor VII (F7 Products)

Background: Human factor VII is a single chain, vitamin K-dependent, plasma glycoprotein which is synthesized in the liver. Prior to secretion into the blood, post translational modification by a vitamin K-dependent carboxylase produces ten-carboxyglutamic acid (gla) residues located in the NH2-terminal portion of the molecule, which facilitate cell membrane binding. Factor VII is proteolytically activated to the serine protease, factor VIIa, during coagulation. Factor VII can be activated by thrombin, factor IXa, factor Xa or factor XIIa.
Description: Human serum/plasma.
Alternative Names: Complement Factor VII

Molecular Weight: 50 kDa

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling