Caspase 1 Protein (CASP1)

Catalog No. ABIN925024

Product Details

Target: Caspase 1 (CASP1)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Bacteria

Characteristics: ~8000 units/mg. One unit cleaves 1 nmol of the caspase substrate YVAD-pNA per hour at 37°C in a reaction solution containing 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10 mM DTT.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with PBS to 1 unit/µl.

Storage: -80 °C

Target Details

Target: Caspase 1 (CASP1)

Alternative Name: Caspase-1 (CASP1 Products)

Synonyms: ICE Protein, IL1BC Protein, P45 Protein, Il1bc Protein, Ice Protein, CASP1 Protein, CG5370 Protein, DCP-1 Protein, DCP1 Protein, Dcp1 Protein, Dmel\\CG5370 Protein, ccp1 Protein, dcp-1 Protein, dcp1 Protein, l(2)01862 Protein, l(2)02132 Protein, caspase 1 Protein, caspase 1, apoptosis-related cysteine peptidase Protein, caspase 4, apoptosis-related cysteine peptidase Protein, Death caspase-1 Protein, caspase-1 Protein, caspase Protein, caspase recruitment domain-containing protein 16 Protein, caspase 4 Protein, CASP1 Protein, Casp1 Protein, CASP4 Protein, Dcp-1 Protein, Caspase1 Protein, LOC5564196 Protein, LOC451519 Protein

Background: Caspase-1 (also known as ICE, Interleulin-1- Converting Enzyme) is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.

Molecular Weight: 45 kDa

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome