ROR2 Protein (Soluble)

Catalog No. ABIN7539348

Product Details

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: Soluble

Origin: Human

Source: Insect Cells

Purpose: ROR2, soluble

Sequence: EVEVLDPNDP LGPLDGQDGP IPTLKGYFLN FLEPVNNITI VQGQTAILHC KVAGNPPPNV RWLKNDAPVV QEPRRIIIRK TEYGSRLRIQ DLDTTDTGYY QCVATNGMKT ITATGVLFVR LGPTHSPNHN FQDDYHEDGF CQPYRGIACA RFIGNRTIYV DSLQMQGEIE NRITAAFTMI GTSTHLSDQC SQFAIPSFCH FVFPLCDARS RTPKPRELCR DECEVLESDL CRQEYTIARS NPLILMRLQL PKCEALPMPE SPDAANCMRI GIPAERLGRY HQCYNGSGMD YRGTASTTKS GHQCQPWALQ HPHSHHLSST DFPELGGGHA YCRNPGGQME GPWCFTQNKN VRMELCDVPS CSPRDSSKMG HHHHHH

Characteristics: Length (aa):376

Purity: > 98 % by SDS-PAGE and Coomassie stain

Application Details

Application Notes: Binds rh Wnt5a in a functional ELISA.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. The lyophilized sROR2 is soluble in water and most aqueous buffers and should be reconstituted in water to a concentration not lower than 100 μg/mL.

Buffer: PBS

Storage: -20 °C,-80 °C

Storage Comment: Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted sROR2 should be stored in working aliquots at -70°C.

Expiry Date: 6 months

Target Details

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2 (ROR2 Products)

Synonyms: BDB Protein, BDB1 Protein, NTRKR2 Protein, Ntrkr2 Protein, mRor2 Protein, ROR2 Protein, bdb Protein, bdb1 Protein, Xror2 Protein, ntrkr2 Protein, MGC97773 Protein, LOC100219935 Protein, ror2 Protein, xror2 Protein, receptor tyrosine kinase like orphan receptor 2 Protein, receptor tyrosine kinase-like orphan receptor 2 Protein, receptor tyrosine kinase like orphan receptor 2 L homeolog Protein, ROR2 Protein, Ror2 Protein, ror2 Protein, ror2.L Protein

Background: Neurotrophic tyrosine kinase, receptor-related 2,ROR2 is a signaling receptor for Wnt ligands that is known to play important roles in limb development, but having no essential roles known in adult tissues. Recent evidence has implicated ROR2 in mediating both canonical and non-canonical signaling pathways. ROR2 was initially found to be highly expressed in osteosarcoma and renal cell carcinomas, and has recently been found in an increasingly long list of cancers currently including melanoma, colon cancer, melanoma, squamous cell carcinoma of the head and neck, and breast cancer. In the majority of these cancer types, ROR2 expression is associated with more aggressive disease states, consistent with a role mediating Wnt signaling regardless of the canonical or non-canonical signal. Because of the pattern of tissue distribution, the association with high-risk diseases, and the cell surface localization of this receptor, ROR2 has been identified as a potential high value target for therapeutic development. However, the recent discovery that ROR2 may function through non-kinase activities challenges this strategy and opens up opportunities to target this important molecule through alternative means.

Molecular Weight: 50.0 kDa

Gene ID: 4920

NCBI Accession: NM_004560, NP_004551

UniProt: Q01974

Pathways: RTK Signaling, WNT Signaling