NR2F2 Protein (His tag)

Catalog No. ABIN7539344

Product Details

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This NR2F2 protein is labelled with His tag.

Purpose: CoupTF2/NR2F2 (fragment)

Sequence: MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEL EHHHHHH

Characteristics: Length (aa):197

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Target Details

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Alternative Name: CoupTF2/NR2F2 (NR2F2 Products)

Synonyms: nr2f2 Protein, MGC52954 Protein, ARP1 Protein, COUPTFB Protein, COUPTFII Protein, NF-E3 Protein, NR2F1 Protein, SVP40 Protein, TFCOUP2 Protein, 2700033K02Rik Protein, 9430015G03Rik Protein, ARP-1 Protein, Aporp1 Protein, COUP-TF2 Protein, COUP-TFII Protein, EAR3 Protein, Tcfcoup2 Protein, Tfcoup2 Protein, fc94g08 Protein, svp40 Protein, svp[40] Protein, wu:fc94g08 Protein, nuclear receptor subfamily 2 group F member 2 L homeolog Protein, Nr2f2 protein Protein, nuclear receptor subfamily 2 group F member 2 Protein, nuclear receptor subfamily 2, group F, member 2 Protein, nr2f2.L Protein, nr2f2 Protein, NR2F2 Protein, Nr2f2 Protein

Background: COUP-TF2, Apolipoprotein A-I regulatory protein 1, ARP-1, COUP transcription factor II, COUP-TF II, Nuclear receptor subfamily 2 group F member 2,Tumor growth depends on nutrients and oxygen supplied by the vasculature through angiogenesis. It was shown that the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a member of the nuclear receptor family, is a major angiogenesis regulator within the tumor microenvironment. COUP-TFs consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). Conditional ablation of COUP-TFII in the tumor microenvironment severely compromised neoangiogenesis and lymphangiogenesis during pancreatic tumor progression and metastasis. It was shown that COUP-TFII plays a cell-autonomous role in endothelial cells to control blood vessel sprouting by regulating cell proliferation and migration. Mechanistic investigations revealed that COUP-TFII suppressed vascular endothelial growth factor receptor-2 (VEGFR-2/KDR) signaling by transcriptionally repressing the expression of VEGFR-1, thereby curtailing a central angiogenic driver of vascular growth. These results implicate COUP-TFII as a critical factor in tumor angiogenesis through regulation of VEGF/VEGFR-2 signaling, suggesting COUP-TFII as a candidate target for antiangiogenic therapy.

Gene ID: 7026

UniProt: P24468

Pathways: Steroid Hormone Mediated Signaling Pathway