Endothelin 1 Protein (EDN1) (His tag)

Catalog No. ABIN7539311

Product Details

Target: Endothelin 1 (EDN1)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Endothelin 1 protein is labelled with His tag.

Purpose: Endothelin-1/ET-1

Sequence: MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH

Characteristics: Length (aa):204

Purity: > 98 % by SDS-PAGE and visualized Coomassie stain

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: water

Buffer: PBS

Target Details

Target: Endothelin 1 (EDN1)

Alternative Name: Endothelin-1/ET-1 (EDN1 Products)

Synonyms: et1 Protein, et-1 Protein, Edn1 Protein, EDN Protein, ET-1 Protein, ET1 Protein, PPET1 Protein, HDLCQ7 Protein, preproET Protein, Et1 Protein, fb14d01 Protein, wu:fb14d01 Protein, PPET-1 Protein, EDN1 Protein, edn1 Protein, edn1-a Protein, edn1-b Protein, endothelin 1 Protein, endothelin 1 S homeolog Protein, endothelin 1 L homeolog Protein, edn1 Protein, EDN1 Protein, Edn1 Protein, edn1.S Protein, edn1.L Protein

Background: Preproendothelin-1, PPET-1, ET-1, EDN1,Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.

Molecular Weight: 26.0 kDa

Gene ID: 1906

NCBI Accession: NM_01955, NP_001946

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size