DKK2 Protein (His tag)
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- Target See all DKK2 Proteins
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DKK2 protein is labelled with His tag.
- Purpose
- Dkk-2
- Sequence
- MKLNSIKSSL GGETPGQAAN RSAGMYQGLA FGGSKKGKNL GQAYPCSSDK ECEVGRYCHS PHQGSSACMV CRRKKKRCHR DGMCCPSTRC NNGICIPVTE SILTPHIPAL DGTRHRDRNH GHYSNHDLGW QNLGRPHTKM SHIKGHEGDP CLRSSDCIEG FCCARHFWTK ICKPVLHQGE VCTKQRKKGS HGLEIFQRCD CAKGLSCKVW KDATYSSKAR LHVCQKITRL EHHHHHH
- Specificity
- Chromosomal location:10q11.2
- Characteristics
- Length (aa):235
- Purity
- 95 % by SDS-PAGE and visualized Coomassie stain
- Top Product
- Discover our top product DKK2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- water
- Buffer
- PBS
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- Target
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Alternative Name
- Dkk-2 (DKK2 Products)
- Synonyms
- DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein
- Background
- Dickkopf-related protein-2, Dickkopf-2,The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling, enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.
- Molecular Weight
- 26.0 kDa
- Gene ID
- 22943
- NCBI Accession
- NM_012242, NP_036374
- UniProt
- O94907
- Pathways
- WNT Signaling
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