VIPR2 Protein

Catalog No. ABIN7538587

Product Details

Target: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human VIPR2 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))

Alternative Name: VIPR2 (VIPR2 Products)

Synonyms: C16DUPq36.3 Protein, DUP7q36.3 Protein, PACAP-R-3 Protein, PACAP-R3 Protein, VIP-R-2 Protein, VPAC2 Protein, VPAC2R Protein, VPCAP2R Protein, VIPR2 Protein, LOC100136266 Protein, Vip2 Protein, pacap Protein, vpac2 Protein, vpac2-R Protein, vpac2-r Protein, vpcap2r Protein, LOC100229999 Protein, vasoactive intestinal peptide receptor 2 Protein, vasoactive intestinal polypeptide receptor type 2 Protein, VIPR2 Protein, LOC100136266 Protein, Vipr2 Protein, vipr2 Protein

Background: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

Molecular Weight: The human full length VIPR2 protein has a MW of 49.5kDa

UniProt: P41587

Pathways: cAMP Metabolic Process