SSR1 Protein

Catalog No. ABIN7538527

Product Details

Target: SSR1 (Signal Sequence Receptor, alpha (SSR1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human SSR1 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: SSR1 (Signal Sequence Receptor, alpha (SSR1))

Alternative Name: SSR1 (SSR1 Products)

Synonyms: cb758 Protein, trapa Protein, Ssr1 Protein, TRAPA Protein, 2510001K09Rik Protein, 6330400D04 Protein, AI159733 Protein, AI452176 Protein, SSR Protein, signal sequence receptor, alpha Protein, signal sequence receptor, alpha (translocon-associated protein alpha) Protein, signal sequence receptor subunit 1 Protein, signal sequence receptor, alpha (translocon-associated protein alpha) S homeolog Protein, ssr1 Protein, SSR1 Protein, Ssr1 Protein, ssr1.S Protein

Background: Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Molecular Weight: The human full length SSR1 protein has a MW of 42.7kDa

UniProt: P30872

Pathways: ER-Nucleus Signaling