5HT1B Receptor Protein

Catalog No. ABIN7538519

Product Details

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human 5HT1B full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Alternative Name: 5HT1B (HTR1B Products)

Synonyms: 5-HT1B Protein, 5-HT1DB Protein, HTR1D2 Protein, HTR1DB Protein, S12 Protein, 5-HT1Db Protein, 5-HT1-LIKE Protein, HTR1B Protein, 5-HT-dro2B Protein, 5-HT1BDro Protein, 5-HT[1B]Dro Protein, 5-HT[[1BDro]] Protein, 5-HT[[1B]] Protein, 5-HT[[1B]]DRO Protein, 5-HT[[1B]]Dro Protein, 5-HT[[dro2B]] Protein, 5HT-R2B Protein, 5HT-dro2B Protein, 5HT-dro[[2B]] Protein, 5HT1B Protein, 5htdro2b Protein, CG15113 Protein, CG30126 Protein, DRO2B Protein, Dm5HTdro2B Protein, Dmel\\CG15113 Protein, Dmel_CG30126 Protein, d5-HT1B Protein, 5-HT-1B Protein, zgc:194666 Protein, zgc:194690 Protein, 5-hydroxytryptamine receptor 1B Protein, 5-hydroxytryptamine (serotonin) receptor 1B Protein, HTR1B Protein, Htr1b Protein, 5-HT1B Protein, htr1b Protein

Background: The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

Molecular Weight: The human full length 5HT1B protein has a MW of 43.6kDa

UniProt: P28222

Pathways: JAK-STAT Signaling, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins