RBM24 Protein

Catalog No. ABIN7538512

Product Details

Target: RBM24 (RNA Binding Motif Protein 24 (RBM24))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human MTR1A full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: RBM24 (RNA Binding Motif Protein 24 (RBM24))

Alternative Name: MTR1A (RBM24 Products)

Synonyms: rbm24-a Protein, seb-4 Protein, seb4 Protein, seb4-a Protein, xseb4 Protein, rbm24 Protein, rnpc1 Protein, rnpc6 Protein, 6330546B05Rik Protein, AI606861 Protein, RNPC6 Protein, dJ259A10.1 Protein, zgc:136803 Protein, RNA binding motif protein 24 S homeolog Protein, RNA binding motif protein 24 L homeolog Protein, RNA binding motif protein 24 Protein, RNA binding motif protein 24a Protein, RNA binding motif protein 24b Protein, rbm24.S Protein, rbm24.L Protein, rbm24 Protein, rbm24a Protein, RBM24 Protein, Rbm24 Protein, rbm24b Protein

Background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length MTR1A protein has a MW of 39.4kDa

UniProt: P48039

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development