RXFP1 Protein

Catalog No. ABIN7538509

Product Details

Target: RXFP1 (Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human RXFP1 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: RXFP1 (Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1))

Alternative Name: RXFP1 (RXFP1 Products)

Synonyms: LGR7 Protein, RXFPR1 Protein, Gm1018 Protein, Lgr7 Protein, RXFP2 Protein, relaxin/insulin like family peptide receptor 1 Protein, relaxin/insulin-like family peptide receptor 1 Protein, RXFP1 Protein, rxfp1 Protein, Rxfp1 Protein

Background: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Molecular Weight: The human full length RXFP1 protein has a MW of 87kDa

UniProt: Q9HBX9

Pathways: Myometrial Relaxation and Contraction