ROR2 Protein (AA 34-403) (His tag)

Catalog No. ABIN7538506

Product Details

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Protein Type: Recombinant

Protein Characteristics: AA 34-403

Origin: Mouse

Source: Mammalian Cells

Purification tag / Conjugate: This ROR2 protein is labelled with His tag.

Purpose: Recombinant mouse ROR2 protein with C-terminal 6xHis tag

Specificity: Mouse ROR2 (Glu34-Gly403) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2 (ROR2 Products)

Synonyms: BDB Protein, BDB1 Protein, NTRKR2 Protein, Ntrkr2 Protein, mRor2 Protein, ROR2 Protein, bdb Protein, bdb1 Protein, Xror2 Protein, ntrkr2 Protein, MGC97773 Protein, LOC100219935 Protein, ror2 Protein, xror2 Protein, receptor tyrosine kinase like orphan receptor 2 Protein, receptor tyrosine kinase-like orphan receptor 2 Protein, receptor tyrosine kinase like orphan receptor 2 L homeolog Protein, ROR2 Protein, Ror2 Protein, ror2 Protein, ror2.L Protein

Background: Enables Wnt-protein binding activity, frizzled binding activity, and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cartilage condensation, cell surface receptor signaling pathway, and embryonic morphogenesis. Predicted to be located in several cellular components, including dendrite, microtubule, and neuronal cell body. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system, embryo mesenchyme, genitourinary system, neural ectoderm, and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome, brachydactyly type B1, and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Molecular Weight: predicted molecular mass of 42.0 kDa after removal of the signal peptide. The apparent molecular mass of mROR2-His is 35-55 kDa due to glycosylation.

UniProt: Q9Z138

Pathways: RTK Signaling, WNT Signaling