P2RY12 Protein

Catalog No. ABIN7538496

Product Details

Target: P2RY12 (Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human P2Y12 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: P2RY12 (Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12))

Alternative Name: P2Y12 (P2RY12 Products)

Synonyms: 2900079B22Rik Protein, 4921504D23Rik Protein, P2Y12 Protein, ADPG-R Protein, BDPLT8 Protein, HORK3 Protein, P2T(AC) Protein, P2Y(12)R Protein, P2Y(AC) Protein, P2Y(ADP) Protein, P2Y(cyc) Protein, SP1999 Protein, P2y12 Protein, purinergic receptor P2Y, G-protein coupled 12 Protein, purinergic receptor P2Y12 Protein, P2ry12 Protein, P2RY12 Protein

Background: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Molecular Weight: The human full length P2Y12 protein has a MW of 39.4kDa

UniProt: Q9H244