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P2RY11 Protein

P2RY11 Origin: Human Host: Mammalian Cells Synthetic Nanodisc
Catalog No. ABIN7538495
  • Target See all P2RY11 products
    P2RY11 (Purinergic Receptor P2Y, G-Protein Coupled, 11 (P2RY11))
    Protein Type
    Synthetic Nanodisc
    Origin
    Human
    Source
    • 1
    • 1
    Mammalian Cells
    Purpose
    Human P2Y11 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    P2RY11 (Purinergic Receptor P2Y, G-Protein Coupled, 11 (P2RY11))
    Alternative Name
    P2Y11 (P2RY11 Products)
    Synonyms
    p2y11 Protein, P2Y11 Protein, purinergic receptor P2Y, G-protein coupled, 11 L homeolog Protein, purinergic receptor P2Y, G-protein coupled, 11 Protein, purinergic receptor P2Y11 Protein, p2ry11.L Protein, p2ry11 Protein, P2RY11 Protein
    Background
    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
    Molecular Weight
    The human full length P2Y11 protein has a MW of 40.3kDa
    UniProt
    Q96G91
    Pathways
    cAMP Metabolic Process
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