OPN1SW Protein

Catalog No. ABIN7538458

Product Details

Target: OPN1SW (Opsin 1 (Cone Pigments), Short-Wave-Sensitive (OPN1SW))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human OPSB full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: OPN1SW (Opsin 1 (Cone Pigments), Short-Wave-Sensitive (OPN1SW))

Alternative Name: OPSB (OPN1SW Products)

Synonyms: SWS2 Protein, bluops Protein, zfblue Protein, SI:zK13A21.5 (blue-sensitive opsin) Protein, Blop Protein, GB13493 Protein, SWS1 Protein, bcp Protein, bop Protein, cbt Protein, CHK-2 Protein, BCP Protein, BOP Protein, CBT Protein, AW551857 Protein, Bcp Protein, opsin 1 (cone pigments), short-wave-sensitive 2 Protein, opsin 1, short wave sensitive Protein, blue-sensitive opsin Protein, KFH-B protein Protein, opsin 1 (cone pigments), short-wave-sensitive Protein, blue sensitive cone opsin Protein, opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Protein, opn1sw2 Protein, OPN1SW Protein, Blop Protein, kfh-b Protein, opn1sw Protein, Opn1sw Protein, OPN2SW Protein

Background: This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length OPSB protein has a MW of 38.7kDa

UniProt: P03999