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NMBR Protein

NMBR Origin: Human Host: Mammalian Cells Synthetic Nanodisc
Catalog No. ABIN7538402
  • Target See all NMBR products
    NMBR (Neuromedin B Receptor (NMBR))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 1
    • 1
    Human
    Source
    • 2
    Mammalian Cells
    Purpose
    Human NMBR full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    NMBR (Neuromedin B Receptor (NMBR))
    Alternative Name
    NMBR (NMBR Products)
    Synonyms
    NMBR Protein, si:dkey-283f18.1 Protein, BB182387 Protein, NMB-R Protein, neuromedin B receptor Protein, NMBR Protein, nmbr Protein, Nmbr Protein
    Background
    This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
    Molecular Weight
    The human full length NMBR protein has a MW of 43.4kDa
    UniProt
    P28336
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